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HCV presents high mutation rates and because of that it has been evolved to different genotypes based on nucleotide sequence heterogeneity and classified in six major genotypes and more than 50 subtypes.9 Molecular epidemiologic studies reveal that HCV genotypes coexist in various geographic locations with different prevalence.9 Several reports have shown prevalence of genotypes 1, 2, 3, 4 and 5 in Latin America.10-12 In Mexico the predominant genotype is 1 (72.2%), followed by genotype 2 (18%) and 3 (9.8%).6 Unfortunately, in Northeast of Mexico, which includes States that are located in the border with USA, there is a little information about frequency of HCV genotypes, and clinical and demographic data in patients infected with HCV.13 In this study we report the distribution of HCV genotypes and the principal risk factors in HCV infected patients from Northeast of Mexico